 【主辦方】瑞典卡羅琳斯卡醫(yī)學(xué)院 【獎(jiǎng)金金額】1100萬瑞典克朗（人民幣7258950元） 【資金來源】阿爾弗雷德·諾貝爾基金會(huì)  https://www./prizes/medicine/2023/summary 天然mRNA（左）和修飾mRNA（右）
 mRNA疫苗發(fā)展歷程,。圖源：Nik Spencer/Nature,；知識分子改編自U. ?ahin et al. Nature Rev. Drug Discov. 13, 759–780 (2014)和X. Hou et al. Nature Rev. Mater. https:///gmjsn5 (2021).  mRNA 接種后棘突的產(chǎn)生及 B 細(xì)胞對棘突的識別,。在脂質(zhì)納米顆粒的促進(jìn)下,，mRNA 進(jìn)入細(xì)胞后，作為棘突蛋白產(chǎn)生的模板,。然后棘突在細(xì)胞表面短暫表達(dá),，在那里它被 B 細(xì)胞通過它們的 B 細(xì)胞受體(BCR)識別，刺激棘突特異性抗體的分泌,。原文鏈接：點(diǎn)擊底部左下角“閱讀原文”可直達(dá) 1. Stanley, M., Tumour virus vaccines: hepatitis B virus and human papillomavirus. Philos Trans R Soc Lond B Biol Sci, 2017. 372(1732). 2. Woolsey, C. and T.W. Geisbert, Current state of Ebola virus vaccines: A snapshot. PLoS Pathog, 2021. 17(12): p. e1010078. 3. Tang, D.C., M. DeVit, and S.A. Johnston, Genetic immunization is a simple method for eliciting an immune response. Nature, 1992. 356(6365): p. 152-4. 4. Martinon, F., et al., Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA. Eur J Immunol, 1993. 23(7): p. 1719-22. 5. Liu, M.A. and J.B. 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