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1084-70ish F with persistent HPV+ ASCH cervical cytology and unsatisfactory colposcopy who underwent LEEP.

Adenoid Basal-like Tumor in Cervical LEEP

Differential Diagnosis

·HPV-associated cervical carcinoma

· Mixed squamous cell carcinoma and adenocarcinoma (”adenosquamous”)

· Adenocarcinoma with areas of stratified mucinous carcinoma (iSMILE)

 · Adenoid basal tumor

·HPV-independent cervical carcinoma

· Mesonephric carcinoma (although these usually arise deep in the cervical wall where mesonephric remnants exist)

· Direct extension of endometrial carcinoma into cervix

Adenoid Basal-Like Tumors of the Cervix

· Rare finding in cervix

· Usually incidental when pure; 

but often admixed with usualtype HPV-associated cervical carcinomas

· Resembles basal cell hyperplasia in the prostate

· Biphasic, nested growth pattern

· Peripheral cells = basaloid with palisading 

· Central cells = glandular

Key Points – Adenoid Basal Tumor

· Rare cervical tumors with a prostatic phenotype 

· Biphasic tumors resembling basal cell hyperplasia of prostate

· NKX3.1+ and HRHPV+ is an unusual IHC combination, unique to this entity

· Adenoid basal tumors are often admixed with traditional HPVassociated adenocarcinoma / squamous cell carcinoma with a minor adenoid basal component 

· Pure adenoid basal tumor is very rare, but have benign behavior thus far

· Must recommend further excision if lesion extends to the margin to 

exclude a component of conventional HPV-associated carcinoma

References

· Stewart CJR, Moses J. NKX3.1 expression in cervical 'adenoid basal cell carcinoma': another gynaecological lesion with prostatic differentiation? Pathology. 2021 Feb;53(2):193-198. Epub 2020 Oct 5. PMID: 33032811.

· Russell MJ, Fadare O. Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts. Diagn Pathol. 2006 Aug 15;1:18.. PMID: 16911774; PMCID: PMC1564042.

1085-永不厭倦經(jīng)典腫瘤類型

女性，30多歲,，大腿有腫塊,。

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病變的兩個組成部分突然轉(zhuǎn)變?yōu)檫吔缜逦慕Y(jié)節(jié),。高級別成分較深，看起來是假包膜的

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低級和高級梭形細(xì)胞成分

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CD34

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高級別成分的過渡和高倍鏡HE

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低級是CD34陽性,，高級幾乎完全失去CD34,。

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這是DFSP的纖維肉瘤樣變。

FISH證實了COL1A1-PDGFB重排,。