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  • Margaret Gelder Ehm, Maha C. Karnoub, Hakan Sakul, Kirby Gottschalk, Donald C. Holt, James L. Weber, David Vaske, David Briley, Linda Briley, Jan Kopf, Patrick McMillen, Quan Nguyen, Melanie Reisman, Eric H. Lai, Geoff Joslyn, Nancy S. Shepherd, et al.
    Received: December 20, 1999Accepted: April 3, 2000
    The American Journal of Human Genetics. Volume 66, Issue 6, Page 1871–1881, Jun 2000
    Corresponding Author: Address for correspondence and reprints: Dr. Margaret Gelder Ehm, Glaxo Wellcome, Inc., P.O. Box 13398, Research Triangle Park, NC 277093398; Email: [email protected]
    Genomewide Search for Type 2 Diabetes Susceptibility Genes in Four American Populations ... the American Diabetes Association GENNID Study Group ... Type 2 diabetes is a serious, genetically influenced disease for which no fully effective treatments are available. ...

  • Robert L. Hanson, Margaret G. Ehm, David J. Pettitt, Michal Prochazka, D. Bruce Thompson, David Timberlake, Tatiana Foroud, Sayuko Kobes, Leslie Baier, Daniel K. Burns, Laura Almasy, John Blangero, W. Timothy Garvey, Peter H. Bennett, and William C. Knowler
    Received: April 28, 1998Accepted: July 17, 1998
    The American Journal of Human Genetics. Volume 63, Issue 4, Page 1130–1138, Oct 1998
    Corresponding Author: Address for correspondence: Dr. Robert L. Hanson, Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014. Email: [email protected]
    An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body‐Mass Index in Pima Indians ... 1Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix: 2Glaxo Wellcome, Inc., Research Triangle Park, NC; 3Department of Statistical Genetics, Sequana Therapeutics, Inc., La Jolla; 4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis; 5Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio; and 6Department of Medicine, Medical University of South Carolina and the Ralph H. Johnson Veteran's Affairs Medical Center, Charleston ... Address for correspondence: Dr. Robert L. Hanson, Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014. ...

  • Robert C. Williams, Jeffrey C. Long, Robert L. Hanson, Maurice L. Sievers, and William C. Knowler
    Received: September 14, 1999Accepted: November 12, 1999
    The American Journal of Human Genetics. Volume 66, Issue 2, Page 527–538, Feb 2000
    Corresponding Author: Address for correspondence and reprints: Dr. Robert C. Williams, Department of Anthropology, Arizona State University, Box 872402, Tempe, AZ 852872402. Email: [email protected]
    Individual Estimates of European Genetic Admixture Associated with Lower Body‐Mass Index, Plasma Glucose, and Prevalence of Type 2 Diabetes in Pima Indians ... 1Department of Anthropology, Arizona State University, Tempe, Arizona; 2Histocompatibility Laboratory, Blood Systems, Inc., Scottsdale, AZ; 3Population Genetics and Linkage Section, National Institute on Alcohol Abuse and Alcoholism, Bethesda; and 4Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes, Digestive, and Kidney Diseases, Phoenix ... A logistic regression was performed on 7,796 persons, to assess association of IA with type 2 diabetes ...

  • Ravindranath Duggirala, John Blangero, Laura Almasy, Thomas D. Dyer, Kenneth L. Williams, Robin J. Leach, Peter O'Connell, and Michael P. Stern
    Received: August 3, 1998Accepted: January 28, 1999
    The American Journal of Human Genetics. Volume 64, Issue 4, Page 1127–1140, Apr 1999
    Corresponding Author: Address for correspondence and reprints: Dr. Ravindranath Duggirala, Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 782847873. Email: [email protected]
    Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans ... We used a variance‐components technique to conduct multipoint linkage analyses for two phenotypes: type 2 diabetes (a discrete trait) and age at onset of diabetes (a truncated quantitative trait). ... We found significant evidence that a susceptibility locus near the marker D10S587 on chromosome 10q influences age at onset of diabetes (LOD score 3.75) and is also linked with type 2 diabetes ...

  • Benedicte A. Lie, John A. Todd, Flemming Pociot, J?rn Nerup, Hanne E. Akselsen, Geir Joner, Knut Dahl‐J?rgensen, Kjersti S. R?nningen, Erik Thorsby, and Dag E. Undlien
    Received: July 16, 1998Accepted: January 13, 1999
    The American Journal of Human Genetics. Volume 64, Issue 3, Page 793–800, Mar 1999
    Corresponding Author: Address for correspondence and reprints: Dr. Benedicte A. Lie, Institute of Transplantation Immunology, The National Hospital, 0027 Oslo, Norway. Email: [email protected]
    Summary

    The human leukocyte antigen (HLA) complex, encompassing 3.5 Mb of DNA from the centromeric HLA‐DPB2 locus to the telomeric HLA‐F locus on chromosome 6p21, encodes a major part of the genetic predisposition to develop type 1 diabetes, designated “...

  • Yusuke Nakagawa, Yoshihiko Kawaguchi, Rebecca C. J. Twells, Claire Muxworthy, Kara M. D. Hunter, Amanda Wilson, Marilyn E. Merriman, Roger D. Cox, Tony Merriman, Francesco Cucca, Patricia A. McKinney, Julian P. H. Shield, Jaakko Tuomilehto, Eva Tuomilehto‐Wolf, Constantin Ionesco‐Tirgoviste, Lorenza Nisticò, Raffaella Buzzetti, Paolo Pozzilli, San‐Raffaele Family Study, et al.
    Received: March 11, 1998Accepted: June 12, 1998
    The American Journal of Human Genetics. Volume 63, Issue 2, Page 547–556, Aug 1998
    Corresponding Author: Address for correspondence and reprints: Prof. John A. Todd,The Wellcome Trust Centre for Human Genetics, Windmill Road,Headington, Oxford, OX3 7BN, United Kingdom. Email: [email protected]
    1The Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Oxford; 2Paediatric Epidemiology Group, Research School of Medicine, University of Leeds, Leeds; 3Institute of Child Health, University of Bristol, Royal Hospital for Sick Children, and 4Department of Diabetes and Metabolism, University of Bristol, Medical School Unit, South Meads Hospital, Bristol; 5Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki; 6Clinic of Nutrition and Metabolic Disease, Bucharest; 7Istituto Biologia Cellulare CNR, Monterotondo, 8Endocrinologia, Istituto Clinica Medica II, University of Roma `La Sapienza,' and 9Libero Istituto Universitario Campus Biomedico, Rome; 10Istituto Scientifico San Raffaele, University of Milan, Milan; 11Aker Diabetes Research Centre, Aker University Hospital, 12Institute of Transplantation Immunology, The National Hospital, and 13Department of Population Health Sciences, National Institute of Public Health, Oslo; 14Steno Diabetes Center, Gentofte, Denmark; and 15Department of Medicine, University of Birmingham, Birmingham Heartlands Hospital, Birmingham, United Kingdom ... Genomewide linkage studies of type 1 diabetes (or insulin‐dependent diabetes mellitus [IDDM]) indicate that several unlinked susceptibility loci can explain the clustering of the disease in families. ... Type 1 diabetes is a common multifactorial disease resulting from an interaction of many genes and, probably, of many environmental factors, resulting in the specific immune‐mediated destruction of the insulin‐producing cells of the pancreas and in life‐long insulin deficiency (Tisch and McDevitt 1996). ...

  • Gienke R. Vreugdenhil, Nanette C. Schloot, Anne Hoorens, Ciska Rongen, Daniel G. Pipeleers, Willem J. G. Melchers, Bart O. Roep, and Jochem M. D. Galama
    Received: 23 December 1999
    Clinical Infectious Diseases. Volume 31, Issue 4, Page 1025–1031, Oct 2000
    Corresponding Author: Reprints or correspondence: Dr J. M. D. Galama, Dept. of Medical Microbiology, University Hospital of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands ([email protected]).
    Acute Onset of Type I Diabetes Mellitus after Severe Echovirus 9 Infection: Putative Pathogenic Pathways ... 1Department of Medical Microbiology, University Hospital, and 2Department of Pediatrics, Canisius Wilhelmina Hospital, Nijmegen, and 3Department of Immunohaematology and Bloodbank, Leiden University Medical Center, Leiden, The Netherlands; and 4Diabetes Research Center, Free University of Brussels, Brussels, Belgium ... Financial support: This work was supported by the Dutch Diabetes Foundation (DFN 94.120), the Juvenile Diabetes Foundation International (JDF‐995004), Belgian Fonds voor Wetenschappelijk Onderzoek (FWO G.0376.97), and the services of the prime minister of Belgium (Interuniversity Attraction Pole P4/21). ...

  • Soumitra Ghosh, Richard M. Watanabe, Timo T. Valle, Elizabeth R. Hauser, Victoria L. Magnuson, Carl D. Langefeld, Delphine S. Ally, Karen L. Mohlke, Kaisa Silander, Kimmo Kohtam?ki, Peter Chines, James Balow, Jr., Gunther Birznieks, Jennie Chang, William Eldridge, et al.
    Received: May 23, 2000Accepted: August 17, 2000
    The American Journal of Human Genetics. Volume 67, Issue 5, Page 1174–1185, Nov 2000
    Corresponding Author: Address for correspondence and reprints: Dr. Michael Boehnke, Department of Biostatistics, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 481092029. Email: [email protected]
    The Finland–United States Investigation of Non–Insulin‐Dependent Diabetes ... I. An Autosomal Genome Scan for Genes That Predispose to Type 2 Diabetes ... 1Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda; 2Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor; 3Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki; 4Department of Physiology and Biophysics and 5Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles; and 6Department of Medicine, University of Washington, Seattle ...

  • Jared C. Roach, Kerry Deutsch, Sarah Li, Andrew F. Siegel, Lynn M. Bekris, Derek C. Einhaus, Colleen M. Sheridan, Gustavo Glusman, Leroy Hood, ?ke Lernmark, and Marta Janer, on behalf of the Swedish Childhood Diabetes Study Group and the Diabetes Incidence in Sweden Study Group
    Received: June 2, 2006Accepted: July 18, 2006
    The American Journal of Human Genetics. Volume 79, Issue 4, Page 614–627, Oct 2006
    Corresponding Author: Address for correspondence and reprints: Dr. Jared C. Roach, Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103. Email: [email protected]
    Genetic Mapping at 3‐Kilobase Resolution Reveals Inositol 1,4,5‐Triphosphate Receptor 3 as a Risk Factor for Type 1 Diabetes in Sweden ... Swedish Childhood Diabetes Study Group and the Diabetes Incidence in Sweden Study Group ... We mapped the genetic influences for type 1 diabetes (T1D), using 2,360 single‐nucleotide polymorphism (SNP) markers in the 4.4‐Mb human major histocompatibility complex (MHC) locus and the adjacent 493 kb centromeric to the MHC, initially in a survey of 363 Swedish T1D cases and controls. ...

  • Julie C. Evans, Timothy M. Frayling, Paul G. Cassell, Philip J. Saker, Graham A. Hitman, Mark Walker, Jonathan C. Levy, Stephen O’Rahilly, Pamidighantam V. Subba Rao, Amanda J. Bennett, Elizabeth C. Jones, Stephan Menzel, Philip Prestwich, Nikol Simecek, Marie Wishart, et al.
    Received: April 5, 2001Accepted: July 12, 2001
    The American Journal of Human Genetics. Volume 69, Issue 3, Page 544–552, Sep 2001
    Corresponding Author: Address for correspondence and reprints: Prof. Andrew T. Hattersley, Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, Barrack Road, Exeter, EX2 5AX, United Kingdom. Email: [email protected]
    Studies of Association between the Gene for Calpain‐10 and Type 2 Diabetes Mellitus in the United Kingdom ... 1Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter, United Kingdom; 2Department of Diabetes and Metabolic Medicine, St. Bartholomew's, and The Royal London School of Medicine and Dentistry, Queen Mary, University of London, and 3Imperial College Genetics and Genomics Research Institute and Division of Medicine, Imperial College, London; 4Department of Medicine, School of Medicine, Newcastle‐upon‐Tyne; 5The Diabetes Research Laboratories, Radcliffe Infirmary, and the 6Wellcome Trust Centre for Human Genetics, Oxford; 7Department of Medicine and Clinical Biochemistry, Cambridge University, Cambridge; 8Plymouth Postgraduate Medical School, Plymouth University, Plymouth, United Kingdom; and 9Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biology, Medicine, and Human Genetics, The University of Chicago, Chicago ... Address for correspondence and reprints: Prof. Andrew T. Hattersley, Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, Barrack Road, Exeter, EX2 5AX, United Kingdom. ...

  • Bruno Ledergerber, Hansjakob Furrer, Martin Rickenbach, Roger Lehmann, Luigia Elzi, Bernard Hirschel, Matthias Cavassini, Enos Bernasconi, Patrick Schmid, Matthias Egger, and Rainer Weber, and the Swiss HIV Cohort Study
    Received: 18 December 2006Accepted: 22 March 2007
    Clinical Infectious Diseases. Volume 45, Issue 1, Page 111–119, Jul 2007
    Corresponding Author: Reprints or correspondence: Dr. Bruno Ledergerber, Div. of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Ramistrasse 100, CH8091 Zurich, Switzerland ([email protected]).
    Factors Associated with the Incidence of Type 2 Diabetes Mellitus in HIV‐Infected Participants in the Swiss HIV Cohort Study ... Divisions of 1Infectious Diseases and Hospital Epidemiology and 2Endocrinology and Diabetes, University Hospital, Zurich, 3Division of Infectious Diseases, University Hospital Berne, and 4Department of Social and Preventive Medicine, University of Berne, Berne, 5Data Centre, Swiss HIV Cohort Study, and 6Division of Infectious Diseases, University Hospital Lausanne, Lausanne, 7Division of Infectious Diseases, University Hospital Basel, Basel, 8Division of Infectious Diseases, University Hospital Geneva, Geneva, 9Ospedale Regionale, Lugano, and 10Division of Infectious Diseases, Cantonal Hospital, St. Gall, Switzerland ... Background.  Human immunodeficiency virus (HIV)–infected persons may be at increased risk for developing type 2 diabetes mellitus because of viral coinfection and adverse effects of treatment. ...

  • Francoise Clerget‐Darpoux
    The American Journal of Human Genetics. Volume 66, Issue 4, Page 1468–1468, Apr 2000
    The HLA Component of Type I Diabetes ... The conclusion of the paper by Lie et al. (1999), that the involvement of the DR‐DQ genes alone does not fully explain the HLA component of insulin‐dependent diabetes mellitus (IDDM), is not a new result. ... Consequently, the conclusion that “the most likely location of the proposed and novel type 1 diabetes involved gene in linkage disequilibrium with D6S2223 would be telomeric of HLA‐F in the vicinity of D6S2223” (Lie et al. (1999, p. 798) ignores these considerations and cannot be reached confidently from the findings reported. ...

  • Benedicte A. Lie, Kjersti S. R?nningen, Hanne E. Akselsen, Erik Thorsby, and Dag E. Undlien
    Received: September 22, 1999Accepted: October 12, 1999
    The American Journal of Human Genetics. Volume 66, Issue 2, Page 740–743, Feb 2000
    Corresponding Author: Address for correspondence and reprints: Dr. Benedicte A. Lie, Institute of Immunology, The National Hospital, N0027 Oslo, Norway. Email: [email protected]
    Application and Interpretation of Transmission/Disequilibrium Tests: Transmission of HLA‐DQ Haplotypes to Unaffected Siblings in 526 Families with Type 1 Diabetes ... To test these two hypotheses empirically, we analyzed the transmission of HLA‐DQA1‐DQB1 haplotypes in 526 Norwegian families with type 1 diabetic children and healthy siblings, since some DQA1‐DQB1 haplotypes represent major genetic risk factors for type 1 diabetes. ... Type 1 diabetes (MIM 142857) is a complex disease for which much effort has been devoted to identifying the predisposing genes. ...

  • Hatem El‐Shanti, Andrew C. Lidral, Nadim Jarrah, Lawrence Druhan, and Kamel Ajlouni
    Received: August 10, 1999Accepted: January 31, 2000
    The American Journal of Human Genetics. Volume 66, Issue 4, Page 1229–1236, Apr 2000
    Corresponding Author: Address for correspondence and reprints: Dr. Andrew C. Lidral, Section of Orthodontics, College of Dentistry, Ohio State University, 4140 Postel Hall, 305 West 12th Avenue, Columbus, OH 43210. Email: [email protected]
    1Departments of Pediatrics and Medical Technology, School of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan; and 3Section of Orthodontics, College of Dentistry, Ohio State University, Columbus ... Wolfram syndrome, which is sometimes referred to as “DIDMOAD” (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is an autosomal recessive neurodegenerative disorder for which only insulin‐dependent diabetes mellitus and optic atrophy are necessary to make the diagnosis. ... There is an absence of diabetes insipidus in all affected family members. ...

  • Flemming Pociot, Allan E. Karlsen, Claus B. Pedersen, Mogens Aalund, J?rn Nerup, and the European Consortium for IDDM Genome Studies
    Received: November 13, 2003Accepted: January 16, 2004
    The American Journal of Human Genetics. Volume 74, Issue 4, Page 647–660, Apr 2004
    Corresponding Author: Address for correspondence and reprints: Dr. Flemming Pociot, Steno Diabetes Center, Niels Steensensvej 2, DK2820 Gentofte, Denmark. Email: [email protected]
    Novel Analytical Methods Applied to Type 1 Diabetes Genome‐Scan Data ... 1Steno Diabetes Center, Gentofte, Denmark, and 2NeuroTech A/S, Copenhagen ... Address for correspondence and reprints: Dr. Flemming Pociot, Steno Diabetes Center, Niels Steensensvej 2, DK‐2820 Gentofte, Denmark. ...

  • Frances Busfield, David L. Duffy, Janine B. Kesting, Shelley M. Walker, 1 Paul K. Lovelock, 1 David Good, Heather Tate, Denise Watego, Maureen Marczak, Noel Hayman, and Joanne T. E. Shaw
    Received: September 17, 2001Accepted: November 7, 2001
    The American Journal of Human Genetics. Volume 70, Issue 2, Page 349–357, Feb 2002
    Corresponding Author: Address for correspondence and reprints: Prof. Joanne Shaw, Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Qld 4102, Australia. Email: [email protected]
    1Department of Diabetes and Endocrinology, Princess Alexandra Hospital, 2Queensland Institute of Medical Research, and 3Inala Community Health Centre, Inala, Brisbane, Queensland; 4Yulu‐Burri‐Ba Aboriginal Corporation for Community Health, North Stradbroke Island, Queensland; and 5Redland Health Service Centre, Cleveland, Queensland ... Address for correspondence and reprints: Prof. Joanne Shaw, Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Qld 4102, Australia. ... The prevalence of type 2 diabetes ...

  • Reimar W. Thomsen, Heidi H. Hundborg, Hans‐Henrik Lervang, S?ren P. Johnsen, Henrik C. Sch?nheyder, and Henrik T. S?rensen
    Received: 13 August 2004Accepted: 14 October 2004
    Clinical Infectious Diseases. Volume 40, Issue 4, Page 628–631, Feb 2005
    Corresponding Author: Reprints or correspondence: Dr. Reimar W. Thomsen, Dept. of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Stengade 10, 2nd Fl., DK9000 Aalborg, Denmark ([email protected]).
    Diabetes Mellitus as a Risk and Prognostic Factor for Community‐Acquired Bacteremia Due to Enterobacteria: A 10‐Year, Population‐Based Study among Adults ... Presented in part: 14th European Congress of Clinical Microbiology and Infectious Diseases, Prague, Czech Republic, 1–4 May 2004 (abstract P466); and 40th European Association for the Study of Diabetes Annual Meeting, Munich, Germany, 5–9 September 2004 (poster 325). ... Diabetes ...

  • Zahid Hassan, Viswananthan Mohan, Liaquat Ali, Rebecca Allotey, Khalid Barakat, M. Omar Faruque, Raj Deepa, Michael F. McDermott, Alan E. Jackson, Paul Cassell, David Curtis, Susan V. Gelding, Shanti Vijayaravaghan, Niklaus Gyr, David C. Whitcomb, et al.
    Received: May 29, 2002Accepted: June 27, 2002
    The American Journal of Human Genetics. Volume 71, Issue 4, Page 964–968, Oct 2002
    Corresponding Author: Address for correspondence and reprints: Dr. G. A. Hitman, Department of Diabetes and Metabolic Medicine, Royal London Hospital, Whitechapel, London E1 1BB, United Kingdom. Email: [email protected]
    SPINK1 Is a Susceptibility Gene for Fibrocalculous Pancreatic Diabetes in Subjects from the Indian Subcontinent ... 1Barts and the London Queen Mary's School of Medicine and Dentistry, London; 2Madras Diabetes Research Foundation, Chennai, India; 3Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh; 4University Hospital Basel, Basel, Switzerland; and 5University of Pittsburgh, Pittsburgh ... Address for correspondence and reprints: Dr. G. A. Hitman, Department of Diabetes and Metabolic Medicine, Royal London Hospital, Whitechapel, London E1 1BB, United Kingdom. ...

  • Haruhiko Osawa, Kazuya Yamada, Hiroshi Onuma, Akiko Murakami, Masaaki Ochi, Hiroko Kawata, Tatsuya Nishimiya, Toshiyuki Niiya, Ikki Shimizu, Wataru Nishida, Mitsuru Hashiramoto, Azuma Kanatsuka, Yasuhisa Fujii, Jun Ohashi, and Hideichi Makino
    Received: May 24, 2004Accepted: July 20, 2004
    The American Journal of Human Genetics. Volume 75, Issue 4, Page 678–686, Oct 2004
    Corresponding Author: Address for correspondence and reprints: Dr. H. Makino, Department of Laboratory Medicine, Ehime University School of Medicine, Shitsukawa, Shigenobu, Ehime 7910295, Japan. Email: [email protected]
    The G/G Genotype of a Resistin Single‐Nucleotide Polymorphism at ?420 Increases Type 2 Diabetes Mellitus Susceptibility by Inducing Promoter Activity through Specific Binding of Sp1/3 ... 1Department of Laboratory Medicine, Ehime University School of Medicine, and 2Ehime Prefectural Hospital, Ehime, Japan; 3Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; 4Chiba Central Medical Center Diabetes Center, Chiba, Japan; and 5Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, and 6Department of Human Genetics, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo ... Insulin resistance is a major cause of type 2 diabetes mellitus (T2DM). ...

  • Kirsten E. Lyke, Nancy S. Miller, Laura Towne, and William G. Merz
    Received: 12 May 2000
    Clinical Infectious Diseases. Volume 32, Issue 8, Page 1178–1187, Apr 2001
    Corresponding Author: Reprints or correspondence: Dr. William G. Merz, Johns Hopkins Medical Institutions, Dept. of Pathology, Division of Medical Microbiology, 600 N. Wolfe St., Meyer B1193, Baltimore, MD 212877093 ([email protected]).
    A Case of Cutaneous Ulcerative Alternariosis: Rare Association with Diabetes Mellitus and Unusual Failure of Itraconazole Treatment ... We describe a case of dermal cutaneous ulcerative alternariosis in a frail 83‐year‐old patient with diet‐controlled diabetes mellitus. ... We review the literature regarding the role of diabetes ...


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