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本公眾號(hào)每天分享一篇最新一期Anesthesia & Analgesia等SCI雜志的摘要翻譯，敬請(qǐng)關(guān)注并提出寶貴意見 The machineries, regulation and cellular functions of mitochondrial calcium 目前，大量研究發(fā)現(xiàn)鈣離子在調(diào)節(jié)細(xì)胞功能中具有重要的作用,，在神經(jīng)傳導(dǎo),、肌肉收縮,、細(xì)胞形態(tài)變化、神經(jīng)細(xì)胞老化,、腺體細(xì)胞的分泌和視網(wǎng)膜細(xì)胞的信號(hào)傳遞等生理過程都有鈣離子的參與,。細(xì)胞的許多功能都依賴于細(xì)胞內(nèi)外極高的鈣離子濃度差存在,，一旦這種濃度差減低,，細(xì)胞功能就會(huì)受到損傷,，甚至引起細(xì)胞死亡。對(duì)于鈣離子信號(hào)通路的研究一直都是醫(yī)學(xué)界的熱點(diǎn)之一,，本綜述描述了不同的鈣離子轉(zhuǎn)運(yùn)體的詳細(xì)分子機(jī)制,，線粒體鈣離子的攝入和流出的調(diào)節(jié)通路機(jī)制，并著重探討了線粒體鈣離子的生理學(xué)機(jī)制以及其在幾種病理情況下的失調(diào)情況,。 鈣離子是最具多樣性的信號(hào)分子之一，參與調(diào)節(jié)多種生理功能,，如肌肉收縮、神經(jīng)元興奮以及細(xì)胞的遷移和生長(zhǎng),。作為細(xì)胞內(nèi)鈣離子重要的調(diào)節(jié)器，線粒體能結(jié)合和釋放鈣離子。此外,，線粒體內(nèi)鈣離子還具有其他重要的功能,，如調(diào)節(jié)線粒體代謝,、ATP的生成以及細(xì)胞凋亡。最近的研究表明,，線粒體內(nèi)鈣離子的積聚和流出能夠調(diào)節(jié)大量病理生理過程,，而這種調(diào)節(jié)依賴于線粒體的穩(wěn)態(tài)。因此,，研究不同細(xì)胞內(nèi)線粒體鈣離子的調(diào)控機(jī)制,，成為目前的研究熱點(diǎn)之一,。 鈣離子信號(hào)通路具有普遍性和多樣性,。鈣離子的普遍性體現(xiàn)在其作為細(xì)胞內(nèi)第二信使無處不在的特點(diǎn),，而其多樣性體現(xiàn)于其能對(duì)不同的空間和時(shí)間信號(hào)做出相應(yīng)的應(yīng)答。在眾多細(xì)胞器中,，線粒體作為鈣離子的調(diào)節(jié)器和解碼器具有重要的地位。由于線粒體具有動(dòng)態(tài)性,，其可以特異性地定位整個(gè)細(xì)胞的位置,，從而改變細(xì)胞內(nèi)的鈣離子應(yīng)答。線粒體作為鈣離子依賴性的效應(yīng)器在很多生化過程中起到重要作用,，例如能量的產(chǎn)生和細(xì)胞死亡,。 原始文獻(xiàn)摘要 Carlotta G , Saverio M , Paolo P . The machineries, regulation and cellular functions of mitochondrial calcium[J]. Nature Reviews Molecular Cell Biology, 2018. Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, neuronal excitability , cell migration and cell growth. By sequestering and releasing Ca2+, mitochondria serve as important regulators of cellular Ca2+. Mitochondrial Ca2+ also has other important functions, such as regulation of mitochondrial metabolism, ATP production and cell death. In recent years, identification of the molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho)physiological conditions that rely on mitochondrial Ca2+ homeostasis. Thus, expanding the understanding of the mechanisms of mitochondrial Ca2+ regulation and function in different cell types is an important task in biomedical research, which offers the possibility of targeting mitochondrial Ca2+ machinery for the treatment of several disorders. 麻醉學(xué)文獻(xiàn)進(jìn)展分享 貴州醫(yī)科大學(xué)高鴻教授課題組 |
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