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本公眾號每天分享一篇最新一期Anesthesia & Analgesia等SCI雜志的摘要翻譯，敬請關注并提出寶貴意見 A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival 背景與目的：miRNA有助于多種基本生物進程,，包括發(fā)育,，增殖，分化和凋亡,。循環(huán)microRNA非常穩(wěn)定,，并且已顯露出作為心血管疾病生物標志物的潛力。急性心肌梗死（AMI）患者的血液中microRNA-208b表達增加,，并且已經被提議作為早期診斷的生物標志物,。在這項初步研究中，我們研究了循環(huán)miR-208b作為AMI患者6個月生存率預后的生物標志物潛力,。  1方法：收集來自21名患者及8名年齡和性別相匹配的健康成年人的血漿樣品,，并使用RT-PCR技術檢測循環(huán)血中miR-208b的表達水平。 結果：健康對照組中miR-208b水平較高（9.6倍;P≤0.05）,。在AMI患者中,，幸存組循環(huán)血中miR-208b的表達水平較非存活組顯著降低（倍數(shù)變化= 6.51和14.1，分別為P≤0.05）,。Kaplan-Meier曲線顯示,，AMI患者的6個月生存率明顯較高，miR-208b的相對表達低于12.38,。循環(huán)血中miR-208b的相對表達危險比（HR）（<12.38為參考）是5.08（95％CI：1.13-22.82; P = 0.03）,。 結論：我們的研究結果表明，miR-208b的表達升高與AMI患者的長期存活率降低相關,。這些試驗數(shù)據表明還需要進行大量的隨訪研究,，以確認miR-208b是否可作為AMI后6個月生存率的預測因子。
Jiang B1, Liu Y1, Liang P2,et al.microRNA-126a-5p enhances myocardial ischemia-reperfusion injury through suppressing Hspb8 expression[J].Oncotarget, Oct 7,，2017;8(55):94172-94187 Introduction miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis. Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease. microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis. In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients.Methods Plasma samples from 21 patients and 8 age- and gender-matched healthy adults were collected, and circulating levels of miR-208b were detected using quantitative real-time PCR.Results miR-208b levels were higher in healthy control subjects (9.6-fold; P ≤ 0.05). Within the AMI patients, the levels of miR-208b were significantly lower in the survivor versus nonsurvivor group (fold change?=?6.51 and 14.1, resp.; P ≤ 0.05). The Kaplan-Meier curve revealed that the 6-month survival time was significantly higher among AMI patients with a relative expression of miR-208b lower than 12.38. The hazard ratio (HR) for the relative expression of miR-208b (<12.38 was the reference) was 5.08 (95% CI: 1.13-22.82; P = 0.03).Conclusion Our results showed that elevated miR-208b expression was associated with reduced long-term survival in AMI patients. These pilot data indicate the need for a large follow-up study to confirm whether miR-208b can be used as a predictor of 6-month survival time after AMI.
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