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Role of gut microbiota in identification of novel TCM-derived active metabolites 腸道菌群在鑒定新型中藥衍生的活性代謝物中的作用 10.1007/s13238-020-00784-w 09-15, Review Abstract & Authors:展開 Abstract:收起
Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.
First Authors:
Tzu-Lung Lin,Chia-Chen Lu Correspondence Authors:
Hsin-Chih Lai All Authors:
Tzu-Lung Lin,Chia-Chen Lu,Wei-Fan Lai,Ting-Shu Wu,Jang-Jih Lu,Young-Mao Chen,Chi-Meng Tzeng,Hongtao Liu,Hong Wei,Hsin-Chih Lai
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