HIV Vaccines and Cure: The Path Towards Finding an Effective Cure and Vaccine

This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

Prospects of Plant-Based Vaccines in Veterinary Medicine

This book provides an in-depth explanation of the advantages and current limitations of recombinant plant-made vaccines for use in veterinary medicine, including for livestock, pets, and wild animals. Written by top scientists in the field, it discusses the background to and latest scientific advances in plant-made vaccines for the most commonly targeted veterinary infections. 

With the recent high-profile research into recombinant plant-made therapeutics for Ebola and Zika viruses, it is likely that the products will be commercialized and widely used in the future. Plant-made therapeutics have a variety of advantages over those made in traditional systems; however, their most fruitful application may be in veterinary medicine, due to less stringent regulations and a greater need for low-cost products.

Vaccines: Are they Worth a Shot? 

The dangerous decline in vaccinations in many developed countries is at the heart of a lively debate that confirms how important the subject is today. Vaccinations are among mankind’s most important scientific discoveries, yet they continue to be viewed with suspicion by part of the public – the victims of disinformation campaigns, instrumentalization and unfounded fears. There is, however, also an evolutionary explanation for these irrational beliefs, and countering the growing social opposition will be extremely difficult without grasping it.

This book, which sheds new light on the safety and importance of vaccinations, is intended both for parents and those readers who want to understand the role of vaccinations in contemporary society, where the ease of access to knowledge is both a great opportunity and a great responsibility. The chapters follow a historical progression and conclude with a discussion of the most recent cognitive theories on how to overcome this opposition to vaccinations.

This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.

Development of Antibody-Based Therapeutics: Translational Considerations & Challenges

With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. 

This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.

Innovations for Next-Generation Antibody-Drug Conjugates

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases.

The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Timely Diagnosis of Colorectal Cancer

This book summarizes current knowledge and outlines directions for the future on how to improve the art of diagnosing colorectal cancer with emphasis on timeliness, one of the most vital issues in cancer management. Using a comprehensive, multi-discliplinary approach, it provides an overview of decisive factors in timely diagnosis of colorectal cancer from symptom scores and symptom awareness to technical aspects.  

The book starts by discussing early diagnosis from the perspective of patients, including the importance of awareness in the general population as well as psychological aspects. It then goes on to discuss issues of importance to clinicians, such as fast tracking, laboratory testing, improving technical skills and optimizing endoscopy services.  In addition, more practical issues such as cost-effectiveness and auditing are also extensively discussed. By focusing on one specific but common form of cancer the content translates well across the scope of other cancer types and can be used by professionals working on different cancer types.

This book provides clinicians, clinical researchers and policymakers with a comprehensive overview of the field of timeliness in diagnosing colorectal cancer. By addressing the challenges posed in the management of symptomatic patients it informs and educates the experts and could help improve diagnosis.

The Infectious Disease Diagnosis: A Case Approach 

This text uses cases  to illustrate differential diagnoses of various infectious diseases.  Unlike any other book on the market, this book is specifically designed for ease of use and can cater to a variety of medical professionals and their needs.  The text features brief cases that allow for quick readability, an appendix particularly designed for cross-referencing cases with common symptoms, exposures, and putative diagnoses, bulleted conclusion points, and differential diagnoses tables. Each case is written by an expert in the field and includes a discussion that leads the reader through the logical process of deduction to narrow the diagnosis as well as the laboratory testing, physical examination findings, and elements of the patient’s history and exposures utilized to make a diagnosis. Chapters conclude with a focused review on a specific topic related to diagnosis, treatment, or prognosis that the case illustrates, including references for further reading on the topics from the literature.  

The Infectious Disease Diagnosis is an outstanding resource for infectious disease specialists, internal medicine physicians, emergency room staff, primary care and general practice physicians, family practitioners, consultants in infectious disease, medical students, residents, fellows, and trainees who diagnose patients.

CURRENT Medical Diagnosis and Treatment 2019

Know what the experts know and incorporate it into your daily practice with the #1 annual guide to internal medicine

INCLUDES 7 ONLINE-ONLY CHAPTERS AT NO ADDITIONAL COST!

Visit: www.AccessMedicine.com/CMDT

Written by clinicians renowned in their respective fields, CMDT offers the most current insight into epidemiology, symptoms, signs, and treatment for more than 1,000 diseases and disorders. For each topic, you’ll find concise, evidence-based answers to questions about hospital and ambulatory medicine. This streamlined clinical companion is the fastest and easiest way to keep abreast of the latest diagnostic advances, prevention strategies, and cost-effective treatments. 

Features and content critical to clinical practice: 

·Strong emphasis on the practical aspects of clinical diagnosis and patient management in all fields of internal medicine

·Full review of all internal medicine and primary care topics, including gynecology and obstetrics, dermatology, neurology, ophthalmology, geriatrics, and palliative care 

·Update of newly emerging infections and their treatments

·Specific disease prevention information

·Hundreds of medication tables, with indexed trade names and updated prices – plus helpful diagnostic and treatment algorithms

·Recent references with PMID numbers

·Full-color photographs and illustrations (many new to this edition)

HERE ARE SOME OF THE MANY UPDATES AND ADDITIONS:

·Revised section on pain management at the end of life

·Updated ACC/AHA guidelines for treatment of valvular disease

·New ACC/AHA and Hypertension Canada blood pressure guidelines

·New FDA approved medications for treatment of breast cancer

·New colon cancer screening recommendations from the U.S. Multi-Society Task Force

·Acclaimed annual update of HIV/AIDS

·New classification of epilepsy

·Revised recommendations for treating hepatitis C virus-associated kidney disease

·Revised chapter on psychiatric disordersNew FDA approved medication for gastric adenocarcinoma 

·Updated information about treating spinal muscular atrophy

Quality Management in Construction Projects, Second Edition

The first edition published in 2010. The response was encouraging and many people appreciated a book that was dedicated to quality management in construction projects. Since it published, ISO 9000: 2008 has been revised and ISO 9000: 2015 has published. The new edition will focus on risk-based thinking which must be considered from the beginning and throughout the project life cycle. There are quality-related topics such as Customer Relationship, Supplier Management, Risk Management, Quality Audits, Tools for Construction Projects, and Quality Management that were not covered in the first edition. Furthermore, some figures and tables needed to be updated to make the book more comprehensive.

Quality

This book offers a comprehensive overview of quality and quality management. It also explores total quality management, covering its human, technological and analytical imperatives. It also examines quality systems and system standards, highlighting essential features and avoiding a reproduction of the ISO 9000 standard, as well as people-related issues in implementing a quality system. A holistic understanding of quality considerations, which now permeate every aspect of human life, should guide related policies, plans and practices. The book describes the all-pervasive characteristics of quality, putting together diverse definitions of 'quality,' outlining its different dimensions, and linking it with reliability and innovation. It goes on to assess the quality of measurements in terms of precision, accuracy and uncertainty and discusses managing quality with a focus on business performance. This is followed by a chapter on improving process quality, which is the summum bonum of quality management, and a chapter addressing the crucial problem of measuring customer satisfaction through appropriate models and tools. Further, it covers non-traditional subjects such as quality of life, quality of working life, quality assurance and improvement in education, with special reference to higher education, quality in research and development and characterizes the quality-related policies and practices in Indian industry. The last chapter provides a broad sketch of some recent advances in statistical methods for quality management. Along with the research community, the book’s content is also useful for practitioners and industry watchers.

External Auditing and Quality

This book focuses on factors impacting audit quality, and solutions to these problems. In addition to elaborating on legislation in the European Union and United States, the book also provides a thorough outlook of Turkish audit market from the point of view of auditing firms and their clients. Many cases and samples are provided to assist practitioners to successfully re-engineer organizational structures in accordance with fresh regulations and expectations of the market. This book serves as a helpful resource for auditing firms, auditors, regulating authorities, as well as post-graduate students of audit sector.

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