臨床科學(xué) Clinical Sciences

腦小血管病新興標(biāo)志物：血管周圍間隙擴(kuò)張程度具有高度遺傳性

Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable

血管周圍間隙擴(kuò)張程度與遺傳密切相關(guān),，腦白質(zhì)和基底節(jié)區(qū)血管周圍間隙擴(kuò)張程度的遺傳差異性,，可以部分解釋疾病進(jìn)程的區(qū)別。(PMID:29311265)

Evros卒中登記研究：希臘東北部卒中發(fā)生率及預(yù)后

Stroke Incidence and Outcomes in Northeastern Greece The Evros Stroke Registry

當(dāng)前希臘規(guī)模最大的基于廣泛人群的卒中登記研究,。(PMID:29335330)

缺血性卒中vs急性心梗：出院1年內(nèi)危險(xiǎn)因素控制的對(duì)比

Comparison of Risk Factor Control in the Year After Discharge for Ischemic Stroke Versus Acute Myocardial Infarction

改進(jìn)卒中后血壓管理策略十分必要,。(PMID:29284738)

北曼哈頓研究：頸動(dòng)脈中膜層厚度與白質(zhì)高信號(hào)有關(guān)

Carotid Intima-Media Thickness Is Associated With White Matter Hyperintensities

The Northern Manhattan Study

頸動(dòng)脈內(nèi)膜-中膜厚度增加與腦白質(zhì)損傷加重有關(guān)，尤其在老年人和拉美裔人群中,。(PMID:29284725)

聯(lián)用質(zhì)子泵抑制劑和氯吡格雷影響腦血管病預(yù)后：系統(tǒng)回顧和Meta分析

Cerebrovascular Outcomes With Proton Pump Inhibitors and Thienopyridines A Systematic Review and Meta-Analysis.

同時(shí)服用質(zhì)子泵抑制劑和氯吡格雷可增加缺血性卒中發(fā)生風(fēng)險(xiǎn)和卒中/心肌梗死/心血管死亡復(fù)合終點(diǎn)的風(fēng)險(xiǎn),。(PMID:29339434）

老年人心率與亞臨床腦血管病的關(guān)系

Association Between Heart Rate and Subclinical Cerebrovascular Disease in the Elderly

一項(xiàng)老年人群為主的隊(duì)列研究結(jié)果表明，夜間心率增加與腦白質(zhì)高信號(hào)有關(guān)，提示心率或?yàn)閬喤R床腦血管病的獨(dú)立危險(xiǎn)因素,。(PMID:29284731）

回顧性分析：腦出血量的半自動(dòng)評(píng)價(jià)方法——基于STICH II隊(duì)列研究

Retrospective Methods Analysis of Semiautomated Intracerebral Hemorrhage Volume Quantification From a Selection of the STICH II Cohort

使用ABC/2.4公式,，量化不規(guī)則形狀的腦出血。(PMID:29321340）

動(dòng)脈瘤性蛛網(wǎng)膜下腔出血后院內(nèi)死亡的預(yù)測(cè)因子

Predictors of In-Hospital Death After Aneurysmal Subarachnoid Hemorrhage

Swiss SOS研究顯示,，以降低再出血風(fēng)險(xiǎn)為目標(biāo)的治療策略,，更適于動(dòng)脈瘤性蛛網(wǎng)膜下腔出血的患者。(PMID:29335333)

前交通動(dòng)脈瘤的發(fā)生與年齡,、分叉角度和血管直徑有關(guān)

Presence of Anterior Communicating Artery Aneurysm Is Associated With Age, Bifurcation Angle, and Vessel Diameter

前交通動(dòng)脈瘤的發(fā)生與病人年齡,，更大的大腦前動(dòng)脈分叉夾角，更小的前交通復(fù)合體區(qū)血管直徑明顯相關(guān),?！驹斠?jiàn)后續(xù)“中國(guó)影響”對(duì)本文的報(bào)道】(PMID:29301972)

自發(fā)性腦出血患者超急性期血壓變化與預(yù)后的關(guān)系

Association Between Hyperacute Stage Blood Pressure Variability and Outcome in Patients With Spontaneous Intracerebral Hemorrhage

腦出血超急性期內(nèi)，血壓變異與不良結(jié)局獨(dú)立相關(guān),?！鞠缕凇笆鲈u(píng)精譯”將對(duì)本文重點(diǎn)點(diǎn)評(píng)】(PMID:29301973)

牙周病、定期牙檢與缺血卒中事件

Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke

牙周病與卒中發(fā)病風(fēng)險(xiǎn)獨(dú)立相關(guān),，尤其是心源性栓塞及血栓性卒中亞型,。規(guī)律的口腔診療可降低卒中風(fēng)險(xiǎn)。(PMID:29335336)

多種族人群中,，R-FSRS評(píng)分,、非傳統(tǒng)風(fēng)險(xiǎn)標(biāo)志物與卒中事件的關(guān)系

Revised Framingham Stroke Risk Score, Nontraditional Risk Markers, and Incident Stroke in a Multiethnic Cohort

改良Framingham卒中風(fēng)險(xiǎn)評(píng)分（R-FSRS）對(duì)卒中發(fā)生具有更好的校準(zhǔn)和判斷力。(PMID:29311270)

模擬不同設(shè)計(jì)下大城市醫(yī)院間轉(zhuǎn)診模式對(duì)卒中預(yù)后的影響

Modeling the Impact of Interhospital Transfer Network Design on Stroke Outcomes in a Large City

在人口密集的市區(qū),，優(yōu)化急性卒中轉(zhuǎn)診網(wǎng)絡(luò)可小幅改善卒中預(yù)后,。(PMID:29343588)

血清肝細(xì)胞生長(zhǎng)因子可能與急性缺血性卒中3個(gè)月預(yù)后有關(guān)

Serum Hepatocyte Growth Factor Is Probably Associated With 3-Month Prognosis of Acute Ischemic Stroke

缺血性卒中患者血清HGF水平升高或與3個(gè)月不良預(yù)后相關(guān)，且獨(dú)立于卒中嚴(yán)重程度,。(PMID:29321335)

 TIA導(dǎo)致遲發(fā)性腦萎縮和認(rèn)知能力下降

Transient Ischemic Attack Results in Delayed Brain Atrophy and Cognitive Decline

前瞻性研究顯示TIA患者會(huì)出現(xiàn)遲發(fā)性的全腦灰質(zhì)和與缺血區(qū)域相關(guān)的局灶性腦萎縮,，并帶來(lái)認(rèn)知功能減退。(PMID:29301970)

側(cè)支循環(huán)與血栓特征的關(guān)系,，以及它們對(duì)前循環(huán)卒中的影響

Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke

血栓較少且血栓影像通透性評(píng)分高者,，側(cè)支循環(huán)評(píng)分更高。血栓影像通透性高對(duì)側(cè)支代償中,、高級(jí)別評(píng)分的患者臨床結(jié)局有益,。(PMID:29321337)

列線圖預(yù)測(cè)靜脈溶栓后癥狀性顱內(nèi)出血風(fēng)險(xiǎn)

STARTING-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis for Stroke

第一個(gè)在大型隊(duì)列中建立并驗(yàn)證的，用于個(gè)體化預(yù)測(cè)靜脈溶栓后癥狀性ICH的列線圖,。(PMID:29311264)

改善溶栓流程與院內(nèi)時(shí)間管理：一項(xiàng)階梯設(shè)計(jì)隨機(jī)對(duì)照試驗(yàn)

Improving Access to Thrombolysis and Inhospital Management Times in Ischemic Stroke

針對(duì)急診專業(yè)人員,，開(kāi)展多元、互動(dòng)的培訓(xùn),，可顯著提高再通率,。(PMID:29321338)

合并隱源性卒中或TIA的卵圓孔未閉患者：手術(shù)與藥物治療的比較

Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack

合并隱源性卒中或TIA的卵圓孔未閉患者,，手術(shù)組缺血性卒中復(fù)發(fā)率更低，但一過(guò)性房顫發(fā)生率更高,。TIA,，全因死亡，心肌梗死則并無(wú)差異,。(PMID:29335335)

男性頸動(dòng)脈粥樣硬化斑的炎癥及鐵代謝水平更高

Carotid Atheroma From Men Has Significantly Higher Levels of Inflammation and Iron Metabolism Enabled by Macrophages

本研究有助于理解粥樣硬化形成和發(fā)展機(jī)制中性別差異和鐵代謝的作用,。(PMID:29284736)

卒中后個(gè)體化健康指導(dǎo)的安全性及有效性：LAST研究

Efficacy and Safety of Individualized Coaching After Stroke: the LAST Study (Life After Stroke)

相比標(biāo)準(zhǔn)治療，定期個(gè)體化健康指導(dǎo),，并不能改善卒中后運(yùn)動(dòng)功能或者其他次要結(jié)局,。(PMID:29284737)

應(yīng)用神經(jīng)影像識(shí)別卒中后康復(fù)最佳獲益人群

Neuroimaging Identifies Patients Most Likely to Respond to a Restorative Stroke Therapy

評(píng)價(jià)亞急性-慢性卒中患者的皮質(zhì)脊髓束損傷百分?jǐn)?shù)，有助于預(yù)測(cè)治療后運(yùn)動(dòng)功能的恢復(fù),。(PMID:29321336)

利用院前分診量表識(shí)別大血管閉塞患者,，對(duì)資源利用及干預(yù)時(shí)間的影響

Impact of Prehospital Triage Scales to Detect Large Vessel Occlusion on Resource Utilization and Time to Treatment

基于卒中嚴(yán)重程度評(píng)分進(jìn)行院前分診是有益的，但尚需隨機(jī)對(duì)照研究證實(shí),。(PMID:29284734)

基礎(chǔ)科學(xué) Basic Science

顱內(nèi)動(dòng)脈瘤相關(guān)的單核苷酸多態(tài)性可改變?nèi)薟illis環(huán)的調(diào)控DNA

Intracranial Aneurysm–Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

本研究的數(shù)據(jù)改進(jìn)了之前關(guān)于與顱內(nèi)動(dòng)脈瘤相關(guān)的單核苷酸的預(yù)測(cè),，并為后續(xù)研究提供優(yōu)先的候選基因。(PMID:29301971)

研究簡(jiǎn)報(bào) Brief Reports

膳食維生素D與卒中或冠心病所致死亡的關(guān)系

Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease  The Japan Collaborative Cohort Study

膳食維生素D或可降低卒中的死亡率,特別是腦內(nèi)出血,。(PMID:29311267)

應(yīng)用無(wú)創(chuàng)腦血氧定量?jī)x檢測(cè)前循環(huán)大動(dòng)脈閉塞

Detection of Anterior Circulation Large Artery Occlusion in Ischemic Stroke Using Noninvasive Cerebral Oximetry

無(wú)創(chuàng)腦血氧定量?jī)x可能有助于鑒別大動(dòng)脈閉塞所致的缺血性卒中,，特別是結(jié)合簡(jiǎn)單的臨床評(píng)分系統(tǒng)能提高診斷準(zhǔn)確率。(PMID:29321339）

ASTER隨機(jī)對(duì)照研究：M2閉塞患者接觸抽吸術(shù)vs支架取栓術(shù)

Contact Aspiration Versus Stent Retriever in Patients With Acute Ischemic Stroke With M2 Occlusion in the ASTER Randomized Trial (Contact Aspiration Versus Stent Retriever for Successful Revascularization)

與支架取栓相比,，血栓接觸抽吸術(shù)并未提高單純M2閉塞所致急性卒中患者的血管再通率,。(PMID:29284735)