曼扭拉曼汀格林是加州大學(xué)河濱分校的細(xì)胞生物學(xué)教授,。隸屬于河濱大學(xué)策略交流部,。

Researchers at the University of California, Riverside have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone. The research could lead to new therapies for preventing cancer metastasis.

在加州大學(xué)河濱分校的研究者剛剛確定了石榴汁當(dāng)中的能抑制癌細(xì)胞擴(kuò)散和弱化誘導(dǎo)前列腺癌細(xì)胞向骨頭轉(zhuǎn)移的化合物,。這項(xiàng)研究將會引發(fā)癌轉(zhuǎn)移的新療法,。

Performed in the lab of Manuela Martins-Green, a professor of cell biology, the research was presented today (Dec. 12, 2010) at the 50th annual meeting of the American Society for Cell Biology taking place in Philadelphia.

今天在曼扭拉曼汀格林研究室,，一個細(xì)胞生物學(xué)教授演示了實(shí)驗(yàn),，就在費(fèi)城美國細(xì)胞生物學(xué)社會50周年紀(jì)念日的開會地點(diǎn),。

Prostate cancer is the second-leading cause of cancer-related deaths in men in the United States. To date, there is no cure for it. If prostate cancer recurs after treatments of surgery and/or radiation, usually the next treatment is the suppression of the male hormone testosterone, which inhibits the growth of the cancer cells because they need this hormone to grow. But over time, the cancer develops ways to resist hormone suppression therapies, becomes very aggressive, and metastasizes to the bone marrow, lungs, and lymph nodes, usually resulting in the patient's death.

前列腺癌是導(dǎo)致美國癌癥男性患者死亡的第二大原因。到現(xiàn)在并沒有一個有效的療法可以治療之,。如果前列腺癌通過化療或手術(shù)得到了治療,，那么下一步將會是對男性激素水平的調(diào)控治療，憑借癌細(xì)胞需要激素生長的條件這個抑制了癌細(xì)胞的生長,。不過經(jīng)過一段時間后,，癌細(xì)胞會產(chǎn)生對調(diào)控藥物的抗性，變得十分好斗,，并轉(zhuǎn)移到骨髓,、肺臟及淋巴結(jié)，通常導(dǎo)致了患者的死亡,。

The Martins-Green lab applied pomegranate juice on laboratory-cultured prostate cancer cells that were resistant to testosterone (the more resistant a cancer cell is to testosterone, the more prone it is to metastasizing).

曼汀格林實(shí)驗(yàn)室在實(shí)驗(yàn)室培養(yǎng)的對調(diào)控激素藥物產(chǎn)生抗性的前列腺癌細(xì)胞上使用了石榴汁（癌細(xì)胞對調(diào)控藥物的抗性越大,，其越容易轉(zhuǎn)移。）

The researchers – Martins-Green, graduate student Lei Wang and undergraduate students Andre Alcon and Jeffrey Ho – found that the pomegranate juice-treated tumor cells that had not died with the treatment showed increased cell adhesion (meaning fewer cells breaking away) and decreased cell migration.

研究者——曼汀格林,，畢業(yè)生王磊和肄業(yè)生安德阿肯和杰夫麗霍－發(fā)現(xiàn)石榴汁治療的腫瘤細(xì)胞并沒有因此死亡,，表現(xiàn)在更好的黏著性（意味著更少的細(xì)胞逃跑了）和減少的細(xì)胞轉(zhuǎn)移量。

Next, the researchers identified the following active groups of ingredients in pomegranate juice that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells: phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids.

下一步,，研究者確定了石榴汁中的對前列腺癌細(xì)胞黏著,、轉(zhuǎn)移起關(guān)鍵作用的活性成分：糖類，氨基酸,，黃酮還是共軛脂肪酸,。

"Having identified them, we can now modify cancer-inhibiting components in pomegranate juice to improve their functions and make them more effective in preventing prostate cancer metastasis, leading to more effective drug therapies," Martins-Green said. "Because the genes and proteins involved in the movement of prostate cancer cells are essentially the same as those involved in the movement of other types of cancer cells, the same modified components of the juice could have a much broader impact in cancer treatment."

“確認(rèn)他們的身份了以后，我們現(xiàn)在能在石榴汁中修改癌抑制化合物,，以提升其在抑制癌細(xì)胞轉(zhuǎn)移的功能,，以達(dá)到更好的藥物治療效果,?！甭「窳终f：”因?yàn)閰⑴c了前列腺癌細(xì)胞的活動的特定的基因和蛋白在其他癌細(xì)胞活動中也起到了相同的作用,，郭治中同樣的化合物可以有在癌癥治療里更為廣泛的治療應(yīng)用,。“

Martins-Green explained that an important protein produced in the bone marrow causes the cancer cells to move to the bone where they can then form new tumors.

曼汀格林結(jié)識骨髓中產(chǎn)生的一種重要的蛋白是導(dǎo)致癌細(xì)胞向其轉(zhuǎn)移并產(chǎn)生腫瘤的重要化學(xué)物質(zhì),。

"We show that pomegranate juice markedly inhibits the function of this protein, and thus this juice has the potential of preventing metastasis of the prostate cancer cells to the bone," Martins-Green said.

”我們演示出石榴汁明顯的抑制了這種蛋白的功能,，因此這種果汁擁有抑制癌細(xì)胞向骨轉(zhuǎn)移的潛能“曼汀格林如是說,。

Next, her lab plans to do additional tests in an in vivo model for prostate cancer metastasis to determine whether the same cancer-inhibiting components that work in cultured cells can prevent metastasis without side effects.

下一步,，她的實(shí)驗(yàn)室準(zhǔn)備進(jìn)行下一步的活體前列腺癌轉(zhuǎn)移實(shí)驗(yàn)來確定是不是同樣的癌抑制化合物可以抑制癌癥的同時不造成副作用,。